Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2

In the current study, an ethyl acetate extract from endophytic fungus Aspergillus sp. SPH2 isolated stem parts of endemic plant Bethencourtia palmensis was screened for its biocontrol properties against pathogens (Fusarium moniliforme, Alternaria alternata, and Botrytis cinerea), insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), parasites (Meloidogyne javanica), ticks (Hyalomma lusitanicum). gave extracts with strong fungicidal ixodicidal effects at different fermentation times. The bioguided isolation these compounds 1–3. Mellein (1) showed also fungicidal. This is first report on 1. Neoaspergillic acid (2) potent antifungal effects. Compound 2 appeared during exponential phase fungal growth while neohydroxyaspergillic (3) stationary phase, suggesting that biosynthetic precursor 3. mycotoxin ochratoxin A not detected under conditions used in this work. Therefore, could be a potential biotechnological tool production rich mellein.